Bacterial vaginosis is a wide distributed polymicrobial infection not considered a sexual transmitted disease, but accompanying several others and constituting their unspecific marker. Also, it has been associated to many important gynecologic and obstetric infectious complications. Prevalence in our setting is high and risk factors described in the literature are very frequent in our population. There are changes in the vaginal ecological system, with decrease in the number of lactobacillus and normal germs and other bacteriae normally present in small numbers proliferate. The most trustful diagnostic method is Nugent’s score. Its natural history is not well known and treatment has been the use of antianaerobial drugs, with relative success.

Bacterial vaginosis is a wide distributed polymicrobial infection not considered a sexual transmitted disease, but accompanying several others and constituting their unspecific marker. Also, it has been associated to many important gynecologic and obstetric infectious complications. Prevalence in our setting is high and risk factors described in the literature are very frequent in our population. There are changes in the vaginal ecological system, with decrease in the number of lactobacillus and normal germs and other bacteriae normally present in small numbers proliferate. The most trustful diagnostic method is Nugent’s score. Its natural history is not well known and treatment has been the use of antianaerobial drugs, with relative success.

Background Little is known about the influence of psychiatric factors on the etiology of placental abruption (PA), an obstetrical condition that complicates 1–2% of pregnancies. We examined the risk of PA in relation to maternal psychiatric symptoms during pregnancy. Methods This case–control study included 373 PA cases and 368 controls delivered at five medical centers in Lima, Peru. Depressive, anxiety and stress symptoms were assessed using the Patient Health Questionnaire (PHQ-9) and the Depression Anxiety Stress Scales (DASS-21). Multivariable logistic regression models were fit to calculate odds ratios (aOR) and 95% confidence intervals (CI) adjusted for confounders. Results Depressive symptoms of increasing severity (using the DASS depression subscale) was associated with PA (p for trend = 0.02). Compared with women with no depressive symptoms, the aOR (95%CI) for PA associate...

Introduction Accumulating epidemiological evidence points to strong genetic susceptibility to placental abruption (PA). However, characterization of genes associated with PA remains incomplete. We conducted a genome-wide association study (GWAS) of PA and a meta-analysis of GWAS. Methods Participants of the Placental Abruption Genetic Epidemiology (PAGE) study, a population based case-control study of PA conducted in Lima, Peru, were genotyped using the Illumina HumanCore-24 BeadChip platform. Genotypes were imputed using the 1000 genomes reference panel, and >4.9 million SNPs that passed quality control were analyzed. We performed a GWAS in PAGE participants (507 PA cases and 1090 controls) and a GWAS meta-analysis in 2512 participants (959 PA cases and 1553 controls) that included PAGE and the previously reported Peruvian Abruptio Placentae Epidemiology (PAPE) study. We fitted popu...

Objective: We sought to evaluate the psychometric properties of two widely used screening scales: the Patient Health Questionnaire (PHQ-9) and Edinburgh Postnatal Depression Scale (EPDS) among pregnant Peruvian women. Methods: This cross-sectional study included 1517 women receiving prenatal care from February 2012 to March 2013. A structured interview was used to collect data using PHQ-9 and EPDS. We examined reliability, construct and concurrent validity between two scales using internal consistency indices, factor structures, correlations, and Cohen׳s kappa. Results: Both scales had good internal consistency (Cronbach׳s alpha>0.8). Correlation between PHQ-9 and EPDS scores was fair (rho=0.52). Based on exploratory factor analysis (EFA), both scales yielded a two-factor structure. EFA including all items from PHQ-9 and EPDS yielded four factors, namely, "somatization", "depression an...