Introduction: COVID 19 collapsed our health system, affecting the entire population, adolescents were a vulnerable group, not only at the socioeconomic and educational level, but also in their mental health, with low vaccination coverage. Objective: To determine the relationship between the level of knowledge and the preventive attitude about COVID19 in adolescents in the jurisdiction of the IPRESS 6 de Octubre and Los Delfines, in the city of Iquitos 2023. Methodology: Quantitative, descriptive, cross-sectional, prospective, correlational, interviewing 142 adolescents from the jurisdiction of the IPRESS 6 de Octubre and Los Delfines, applying a validated questionnaire to determine the level of knowledge and their preventive attitude about COVID19. Results: The level of knowledge of adolescents about COVID 19 was adequate in more than 50% and poor in 40%. Adolescents presented an adequat...