Background: The psychosocial effects derived from the COVID-19 pandemic have represented a challenge for the population worldwide. Stress is a frequent problem reported by women, impacting the strategies they use to deal with problems in daily life and their ability to recover from this critical phenomenon. Objective: The objective of this study was to evaluate the relationship between stress levels, knowledge about COVID -19, ways of coping, and resilience in women. Method: A non-experimental, cross-sectional, and correlational study was carried out in a group of 386 Mexican women through a format that was distributed on social networks. Results: The data suggest that the higher the level of knowledge about COVID-19, the greater the perceived stress. High stress is positively and statistically significantly related to coping style, denial (r = .245; q = .20) and cognitive-reflective ana...