The main of this case was to investigate the benefits of photodynamic therapy (PDT) in application cycles as a method of treatment of medication-related osteonecrosis of the jaw (MRONJ), reporting the case of a 75-year-old white male patient with a diagnosis of renal malignancy with lung and bone metastases treated with sunitinib malate and denosumab. The patient was referred for dental evaluation in an office set up to attend patients with special needs, in the city of Salvador-Ba. In the intraoral examination, areas of exposed and necrotic bone tissue were observed in the mandible (medial aspect) on both sides, close to the molar region, with an ulcerative appearance, three millimeters in diameter, and the diagnostic hypothesis was stage 2 ONMRM The application protocol of 20 PDT cycles was started, as the only form of treatment, in two weekly sessions with preventive laser therapy for...