Introduction: Transplantation is the treatment of choice in patients with chronic kidney disease (CKD). It requires immunosuppression, which predisposes to the development of complications. Chronic rhinosinusitis (CRS) is one of the most important. Objective: To compare the characteristics of patients with CKD with and without CRS undergoing renal transplantation protocol in a concentration Hospital in Puebla, Mexico. Methods: Comparative, cross-sectional, retrospective study in patients in a tertiary care hospital with CKD and undergoing renal transplantation protocol. The SNOT-22 and Lund-Mackay scales were applied. Descriptive statistics and Mann-Whitney U test, Fisher's exact test and Phi coefficient were used; p<0.05 was considered significant. Results: 360 patients were recruited, 49 presented CRS, prevalence: 13.61%. Means: age: 39.22 ±12.09 years and evolution time: 17.73 ±5...