Pituitary stalk interruption syndrome (PSIS) is a congenital genetic disorder that causes hypopituitarism, which is characterized by hypoplasia of the adenohypophysis, ectopic neurohypophysis and pituitary stalk interruption. The clinical manifestations are related to varying degrees of pituitary hormone deficiency (panhypopituitarism). The diagnosis is usually made late or goes unnoticed because it depends on the clinical manifestations presented, a fact that is associated with high morbidity and mortality in patients. We present the case of a 19-year-old female patient with a pathological history of nystagmus, toxoplasmosis, stunted growth and delayed pubertal development. She was admitted to the hospital emergency room because she presented with fever, dyspnea, polyarthralgia, headache, vomiting and oral intolerance. During hospitalization, sustained hypoglycemia refractory to the adm...