The purpose of this report on pre-professional practices was to compare the consumption of medications before and after the implementation of the Antimicrobial Optimization Program (PROA) at the Víctor Lazarte Echegaray Hospital. The sample consisted of patients treated in the Medicine and Surgery B services, before the implementation of the PROA in the period April 2017 - March 2018 and after the implementation of the PROA in the period April 2018 - March 2019. The method used It was the international technique for measuring the consumption of medicines, Defined Daily Dose, with which the consumption was evaluated by means of DDD / 100camas / day of ceftriaxone 1g, cefepime 1g and vancomycin 500mg. The results before the implementation of the PROA in the Medicine and Surgery B Services were for ceftriaxone 5.63 (62%) and 19.90 (77%), cefepime 5.73 (72%) and 1.26 (74%) ) and vancomycin ...