Due to its complex topography, the Lake Titicaca region, located in the southern tropical Andes, presents great challenges for atmospheric modeling. This study aims to improve the representation of precipitation and air surface temperature using the Weather Research and Forecasting (WRF) model at high spatial resolution (2 km), during the austral summer of 2020. We conducted 11 experiments with different configurations of topography, land use, physical parameterizations, and lake surface temperature (LST). Each experiment was evaluated considering in-situ data from the Peruvian-Bolivian region and gridded precipitation products. For precipitation, the best configuration, with an average bias close to zero mm, includes using the GMTED2010 topography (not smoothed) and the land use data of Eva et al. (2004), along with the Purdue Lin microphysics and the Grell 3D cumulus scheme. For air te...