When it is necessary to complete a treatment in more than one appointment, it is recommended to place an intracanal medication in order toavoidthedevelopmentofmicroorganisms. Thereareseveraloptions; however, it dependsontheprofessionaltodecidewhichmedication is suitableforeachcase, hencethe idea of an associationbetweenthe different intracanalmedications. Inview of the antimicrobial, reducing, and anti-inflammatory properties of calcium hydroxide, an association with chlorhexidine, anti-inflammatory, antibiotics or others substances has been sought. Once a paste of calcium hydroxide and chlorhexidine with different concentrations is prepared, the renewal of the tissue and microbial elimination was observed; however, this action did not outweigh the action of the chlorhexidine isolated, then we conclude that there is no potentiation in the combination of these drugs. On the other hand, so...