The objective was to determine the association between risk factors and mental illness in Nursing students of the National University of the Peruvian Amazon Iquitos 2023, the type of research was quantitative, descriptive, correlational; the design was non-experimental, cross-sectional; The target population was 360 students and the sample was 186, the Chi-square statistical test was applied; The instruments were the Risk Factor Registration Form, Rosemberg Self-Esteem Scale and Symptom Questionnaire (SRQ); The main findings were; There is a statistically significant association between risk factors, young age and absence of anxiety (p=0.001); female gender and absence of anxiety (p=0.000) and absence of depression (p=0.008); child abuse and absence of anxiety (p=0.001), absence of depression (p=0.008); no drug use and absence of anxiety (p=0.007), absence of depression (p=0.001) and no ...