This article defines the roles of colors and presents their historical development as a fundamental means of expression within artwork. It also introduces color theorists and practices, including the mixing of pigments, a necessary technique for artists-designers in creating tangible results. Modern artists-designers have used these theorists to express themselves in producing an aesthetic experience in the viewer through their artwork, starting with Sir Isaac Newton’s light-spectrum experiments using a glass prism and a beam of white light, and continuing through Johannes Itten’s color-wheel and creative color-matching exercises. This article objective defines the significance of color, its historical development on the basis of earlier perceptual theorists’ findings that color acquires dimension and meaning in response to cultural-historical context or psychological realities. As...