Humans are at the heart of crucial processes in warehouses. Besides the common economic goal of minimising cycle times, we therefore add in this paper the human well-being goal of minimising workers’ discomfort in the context of order picking. We propose a methodology for identifying the most suitable storage location solutions with respect to both goals. The first step in our methodology is to build data-driven empirical models for estimating cycle times and workers’ discomfort. The second step of the methodology entails the use of these empirically grounded models to formulate a bi-objective assignment problem for assigning products to storage locations. The developed methodology is subsequently tested on two actual warehouses. The results of these practical tests show that clear trade-offs exist and that optimising only for discomfort can be costly in terms of cycle time. Based on...