Introduction: Generative Artificial Intelligence (AI), such as ChatGPT, has transformed higher education by facilitating autonomous learning and content generation. However, its adoption poses challenges regarding academic integrity, assessment, and ethics. To ensure its responsible use, it is essential to analyze the factors influencing its acceptance. Objective: To identify theoretical models, analyzed factors, research methods, data analysis techniques, and sampling approaches in studies on ChatGPT in higher education. Method: A systematic literature review was conducted following the PRISMA methodology, searching ScienceDirect, PubMed, and EBSCOhost (September 2023 – September 2024). Methodological quality was assessed using the Critical Appraisal Checklist for Analytical Cross-Sectional Studies (JBI) and the standards of Ijaz and Yadegaridehkordi (2024). A total of 27 studies were...