Our interest in handling animal species with the purpose of experimentation and pharmacokinetic study, due to the necessity of more rational guidelines, have motivated us to develop the present study in six healthy young ostriches to whom we administered diazepam (DZP) and midazolam (MDZ) via IV and IM in a simple dose of O,5mg/kg. By HPLC/u.v quantification (220nm) we observed that pharmacokinetics parameters of DZP after IV administration, corresponded to MRTt=71,17±29,97min, t1/2β=49,30±21,18min, Cl=87±50mLlkglmin and Vcc=1,82±O,35L/kg. The plasma DZP concentrations post IM administration and the two main active metabolites concentrations after IV/IM administration did not allow a kinetic treatment of them. The pharmacokinetics parameters of MDZ after IV and IM administration respectively corresponded to MRTi=59,70±37,14 and 50,09±12,71min, t1/2β=39,64±25,30 and 35,32±1O,93m...

Our interest in handling animal species with the purpose of experimentation and pharmacokinetic study, due to the necessity of more rational guidelines, have motivated us to develop the present study in six healthy young ostriches to whom we administered diazepam (DZP) and midazolam (MDZ) via IV and IM in a simple dose of O,5mg/kg. By HPLC/u.v quantification (220nm) we observed that pharmacokinetics parameters of DZP after IV administration, corresponded to MRTt=71,17±29,97min, t1/2β=49,30±21,18min, Cl=87±50mLlkglmin and Vcc=1,82±O,35L/kg. The plasma DZP concentrations post IM administration and the two main active metabolites concentrations after IV/IM administration did not allow a kinetic treatment of them. The pharmacokinetics parameters of MDZ after IV and IM administration respectively corresponded to MRTi=59,70±37,14 and 50,09±12,71min, t1/2β=39,64±25,30 and 35,32±1O,93m...