Metronidazole-induced neurotoxicity is an uncommon but underestimated complication in patients with prolonged exposure. We present the case of a 67-year-old male who presented with ataxia and seizures after receiving metronidazole and ceftriaxone for 65 days. The brain MRI showed typical lesions in the dentate nucleus, mesencephalon, and corpus callosum. Clinical and radiographic improvements were observed after stopping the antimicrobial. This case report emphasizes the importance of considering this entity in the differential diagnosis of neurologic derangement during prolonged antibiotic therapy, identifies MRI as a key diagnostic tool, and increases awareness to minimize serious adverse effects.

No description

Nocardia infections exhibit diverse clinical manifestations, pulmonary nocardiosis (PN) is the most common. In countries with a high burden of MDR TB such as Peru, co-infection with Nocardia is possible. We report the case of a 91-year-old male with cough, malaise, and weight loss, initially treated for pulmonary tuberculosis (sputum BK positive) without improvement. Subsequent testing with MALDI-TOF identified Nocardia cyriacigeorgica in sputum, confirming coinfection with Mycobacterium tuberculosis sensitive to rifampin detected through real-time PCR. Rapid diagnostic tools such as PCR and MALDI-TOF enhance diagnostic precision; however, their interpretation must consider individual risk factors to avoid overtreatment and ensure an appropriate therapeutic regimen.