Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 4...

El objetivo de este estudio fue evaluar la incidencia acumulada, los factores de riesgo y de protección, y el impacto en la mortalidad de la enfermedad cardíaca primaria (pericarditis, miocarditis, endocarditis, arritmias y/o anomalías valvulares) en pacientes con lupus eritematoso sistémico (con duración de la enfermedad mayor o igual a 2 años) de una población multiétnica, internacional y cohorte de inicio longitudinal (34 centros, 9 países latinoamericanos).