Introduction: SARS-CoV-2 virus causing COVID-19 disease, was first discovered in Wuhan, China in December 2019. Peru was one of the countries with the most alarming figures. The mortality rate as of April 13, 2023 was 674.3.Regionally,the city of Moquegua ranked fourth with a figure of 891. 9 preceded by Callao, Ica and Metropolitan Lima and was associated with various risk factors, such as hyperglycemia Objective: To determine whether hyperglycemia on admission is a prognostic factor for unfavorable outcome in patients hospitalized with COVID-19 at the Regional Hospital of Moquegua during the first and second epidemiological wave of SARS-CoV-2.Materials and methods: An observational, analytical, cohort, retrospective study was carried out with the application of a data collection form. A sample of 640 medical records was obtained by simple random probability sampling. Data processing wa...