We present the case of a 91-year-old female, patient hospitalized for operative wound infection secondary to hip surgery. Antibiotic treatment with meropenem was administered, presenting at 4 days: fever, asthenia and disseminated erythematous rash with non-follicular pustules predominantly of the trunk, extremities and fold areas; In addition, leukocytosis is found with neutrophilia. Histopathological study of skin biopsy showed subcorneal pustules with exocytosis of neutrophils. Antibiotic was discontinued, with clinical improvement 5 days after the suspension of meropenem. There are few reports of cases of acute generalized exanthematous pustulosis caused by meropenem.

Tuberculosis is highly prevalent and is still currently the leading cause of adrenal insufficiency in many areas of the world. Clinically this disease remains asymptomatic during early stages, but due to adrenal function loss symptoms become insidious and gradual, mostly unspecific. We report two cases of female patients with clinical symptoms of chronic bilateral primary adrenal insufficiency with active tuberculosis infection by histopathology.

We present the case of a 69-year-old male patient with tumor lesion in the left inguinal region, asymptomatic. The histopathological and immunohistochemical study was consistent with ecrine porocarcinoma. Upon imaging, nodal metastases in the iliac femoral, retroperitoneal and supraclavicular left region are evident. Ecrine porocarcinoma infiltration into supraclavicular ganglion is confirmed at histopathological study. Metastatic eccrine porocarcinoma is very rare. Surgical treatment is not possible in these cases. There is no standard systemic treatment, only case series with variable responses. Our patient received chemotherapy treatment with doxetacel with good clinical response to follow-up.