Dear Editor,We have carefully read the article titled "Association between Anxiety andDepression in Medical Students at Universidad Ricardo Palma during 2021" (1),published in the fourth issue of volume 22 (2022) of the Revista de la Facultadde Medicina Humana. The authors conducted a cross-sectional study with theobjective of determining the association between anxiety and depression inmedical students at Universidad Ricardo Palma. Below, we present somecomments that we consider pertinent

Objective: To describe the learning achievement after training in pharmacogenetics based on PBL and ICT and its persistence four years later in human medicine students of a public university in Peru. Materials and Methods: 160 students who received training on the pharmacogenetics of warfarin applying PBL and ICT were evaluated. The instrument was based on a clinical problem applied immediately after training and 4 years later. Results: Results of the first evaluation indicated a good analytical resolution of the problem with argumentation in the genetic conditions of the patient. The evaluation after four years showed that 89% of the students continued at higher levels of learning. Conclusion: It was shown that the use of a meaningful learning methodology with PBL and ICT can make knowledge last and serve in the future for decision-making in the selection of medication.