The negative effects of human activities on biodiversity highlight the vulnerability of amphibians, positioning them as the most affected group of vertebrates globally, constituting approximately 41% of all species. Therefore, the objective of this research is to describe the effects of exposure to heavy metals in anurans, analyzing impacts on various organs, both in terms of acute and chronic effects. A search for information was conducted in databases such as Scopus, ScienceDirect, ResearchGate, Research4life, Scielo, CABI, Springer, Wiley, ProQuest, PubMed, Redalyc, and Google Scholar. The PRISMA approach was employed for the analysis and selection of information, resulting in the selection of 56 articles for the present systematic review. Most analyzed articles focused on the larval evaluation of anurans, highlighting cadmium as a recurring metal due to its natural presence. Addition...