The Bolivian tin belt is a metallogenic province in the Eastern Cordillera of the Andes known for its Sn, W, Ag, and base metal deposits. Cassiterite, which is a major constituent in many magmatic-hydrothermal ore deposits from the Bolivian tin belt, can incorporate dozens of elements within its crystal lattice, making it a useful geological tracer mineral and also a potential host of critical elements. New U-Pb dating of cassiterite yields Late Triassic (Kellhuani deposit) and Late Oligocene to earliest Miocene (Viloco, Huanuni, and Llallagua deposits) ages. These ages confirm that Sn mineralization in the Bolivian tin belt occurred at least in two separate events during two major magmatic episodes apparently triggered by mantle upwelling, decompression melting, and basalt production promoting high heat flow into the overlying crust. The composition of studied hydrothermal cassiterite y...