Basin-scale simulation is fundamental to understand the hydrological cycle, and in identifying information essential for water management. Accordingly, the Soil and Water Assessment Tool (SWAT) model is applied to simulate runoff in the semi-arid Tambo River Basin in southern Peru, where economic activities are driven by the availability of water. The SWAT model was calibrated using the Sequential Uncertainty Fitting Ver-2 (SUFI-2) algorithm and two objective functions namely the Nash-Sutcliffe simulation efficiency (NSE), and coefficient of determination (R2) for the period 1994 to 2001 which includes an initial warm-up period of 3 years; it was then validated for 2002 to 2016 using daily river discharge values. The best results were obtained using the objective function R2; a comparison of results of the daily and monthly performance evaluation between the calibration period and valida...