Objetivos Sintetizar dos complejos de Cobalto (II) con pirazinamida (PZA): Co-PZA (1) y Co-PZA (2), utilizando dos sales precursoras de cobalto: CoCl2.6H2O y Co(NO3)2.6H2O respectivamente. Caracterizar los complejos Co-PZA (1) y Co-PZA (2) utilizando técnicas fundamentales fisicoquímica y de espectrofotometría. Elucidar y proponer tanto la fórmula molecular como la estructura química para cada complejo sintetizado en base a los resultados de la caracterización. Evaluar la actividad biológica de los complejos, enfocando la actividad antituberculosa, para ello se propone: 1. Determinar la concentración mínima inhibitoria (MIC) de los complejos frente a un cultivo microbiológico TEMA, utilizando cepas de M. tuberculosis nativas H37Rv y cepas altamente resistentes denominadas multidrogorresistentes (MDR). 2. Evaluar la concentración de producción de ácido pirazinoico mediante un...

In this study, two new cobalt with pyrazinamide (PZA) coordination compounds: Co-PZA (1) and Co-PZA (2) were synthesized from two cobalt precursor salts. The aim of this study is to elucidate the chemical structure of each synthesized complex by using characterization techniques, as well as to evaluate their anti-tuberculous activity compared to pyrazinamide. The characterization techniques comprised, C, H and N elemental analysis, atomic absorption spectroscopy of cobalt, thermogravimetric analysis, magnetic susceptibility, UV-Visible, infrared and Raman spectroscopy. The antibiotic activity was tested by determining the minimum inhibitory concentration in a Mycobacterium tuberculosis culture. The predicted molecular formulas from characterization results were: [Co(PZA)2Cl2] for Co-PZA (1) complex and [Co(PZA)2(NO3)2].H2O for Co-PZA (2) complex. The two complexes showed a higher antimic...