Domestic wastewater is dumped directly into the water resource affecting it, for which it is important to implement environmental control and prevention. In this research, the aim is to determine the efficiency of Zantedeschia aethiopica (Water Lily) and Nasturtium officinale (Water cress) in the removal of COD and BOD5 in the domestic wastewater of the Santiago Antúnez of Mayolo El Tambo Urbanization - 2021. To achieve the objective was to collect 36 L of domestic wastewater from the Santiago Antúnez de Mayolo El Tambo Urbanization, which were placed in three glass ponds of 35 cm x 25 cm x 25 cm, which each contained 12 liters of water ; the first pond was considered as zero treatment (T0) or control treatment, In the second pond, the Zantedeschia aethiopica (Water Lily) species was placed and it was considered as treatment one (T1) and in the third pond the Nasturtium officinale (Wat...