Method: The Systematic Review design was used, the search was limited to articles with full text, subjected to a critical reading, using the Jover evaluation to identify its degree of evidence. Results: 10 articles corresponding to China 20%, Canada 30%, 10% Australia, Sweden 10% and USA 30% were selected comparatively. 40% of the studies stated that there were no significant differences in complications that require the elimination of the PICC, 40% expressed that the non-central position is a risk factor for complications and elimination, whose tendency increases in MS and 20% stated that the PICC placement in MI is associated with significantly higher risk of complications. Conclusions: Of the 10 articles systematically reviewed, 6/10 evidenced mechanical complications and infection according to the insertion site, adding that the central location of the PICC tip can have a significant...