Alkaline proteases are a physiologically and commercially important group, used primarily as detergent additives and food processing. The objective of this research was to isolate and select native Bacillus sp. Protease producers from compost of the Experimental Station of Applied Biochemistry, National University of Trujillo, Perú. For this purpose, compost was collected as a sample, enriched with a 1% casein solution, and a thermal treatment (80 °C for 15 minutes). To isolate the native Bacillus, serial dilutions were made, and 0.1 mL per surface were plated on Casein Agar plates and incubated at 37 ° C for 24 to 48 hours. The selected bacterial cultures were placed in stirred system bioreactors containing Casein Broth at room temperature (23 ° C - 25 ° C), and every 24 hours (0, 24, 48, 72, 96, 120 and 144 h) was determined the production of proteases by extracting 8 mL of sample...