Condylar hyperactivity (CH) is a rare condition that entails a progressive deviation and deformation of the mandible. There is no consensus regarding characteristic histopathological features or a standardized diagnostic process; thus, histopathological analysis of the condyle cannot confirm or exclude an active CH after condylectomy is performed. An electronic search was performed in Medline, Embase, Web of Science, LILACS and grey literature up to December 2019. Additionally, a manual search was performed. Risk of bias of the included studies was assessed using the Newcastle–Ottawa Scale and the Institute of Health Economics Quality Appraisal. All analyses were performed independently and in duplicate. Seventeen articles from 660 were included. Six articles were crosssectional studies and 11 were case series. Almost all the articles (14) described an augmented thickness of the cartil...

Objective: This systematic review evaluates the effect of laser gingivectomy on the improvement of periodontal health parameters in patients with gingival enlargement due to fixed orthodontic appliances. Materials and methods: A systematic review was conducted in 3 databases without language or date restrictions. Clinical trials involving patients with gingival enlargement (GE) or hyperplasia induced by fixed orthodontic treatment and treated by laser gingivectomy, conventional surgery (scalpel) or non-surgical periodontal treatment (NSPT) were included regarding periodontal parameters such as bleeding on probing, probing depth, gingival inflammation, among others. Results: From the 363 articles initially retrieved, only 6 were included after evaluation of the full text. However, all studies were considered to have a high risk of bias. It was detected that periodontal parameters (bleedin...

The development of extracellular vesicles (EVs) therapies has revolutionized personalized medicine, opening up new possibilities for treatment. EVs have emerged as a promising therapeutic tool within this field due to their crucial role in intercellular communication across various cell types and organisms. This systematic review aims to evaluate the therapeutic potential of oral mesenchymal stem cell (MSC)-derived EVs for bone regeneration, specifically focusing on findings from preclinical models. Sixteen articles meeting the inclusion criteria were selected following document analysis. The biological effects of oral MSC-derived EVs predominantly involve the upregulation of proteins associated with angiogenesis, and inflammation resolution, alongside the downregulation of proinflammatory cytokines. Moreover, these therapeutic agents have been found to contain a significant quantity of ...