Objective: To determine the relationship between motivation and academic performance of Human Medicine students at the Universidad Nacional Jorge Basadre Grohmann in 2021. Material and methods: Observational, analytical, and transverse study carried out on 88 students from the second to the sixth year enrolled in the 2021-II cycle of the human medicine career of the National University Jorge Basadre Grohmann. An anonymous virtual survey after the informed consent was applied, with an adapted instrument of academic self-regulation (SRQ-A), based on the self-determination theory of motivation and regulation, with four subscales that were grouped into two dimensions: autonomous motivation (MA) that covers identified regulation and intrinsic motivation, and controlled motivation (MC) that covers introjected regulation and external regulation. Pearson’s correlation and ANOVA test were used,...