In current clinical oncology, transitional cell carcinoma of the bladder serves as a highly representative model for development in basic, pathogenic and therapeutic research. This casereport presents a transitional cell carcinoma of the bladder with a diagnostic approach thatintegrates clinical and imaging methods. The patient is a 67-year-old white male with a historyof macroscopic hematuria who was referred for diagnostic imaging. A lower abdominal ultrasoundrevealed a focal exophytic lesion with features suggestive of neoplastic proliferation. Non-contrastand contrast-enhanced computed tomography (CT) scans were performed for staging purposesand to further assess possible secondary infiltration into adjacent organs, including pelvic lymphnodes, and systemic metastases. The study was complemented by cystoscopy, which showed focalmural thickening within the organ, caused by a fluctuati...