High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechanisms. Failing to adapt to chronic HA exposure leads to a disease called chronic mountain sickness (CMS) characterized by excessive erythrocytosis (hemoglobin [Hb] ≥19 g/dL for women and ≥21 g/dL for men). Genes encoding for peroxisome proliferator-activated receptor (PPAR) subunits α and γ have been proposed as candidate genes for HA adaptation. N-acylethanolamides (NAEs) are endogenous fatty acid substances that bind to PPAR-α and -γ. NAEs are also able to modulate the endocannabinoid system, a signaling pathway activated in physiological stressful conditions. In the frame of a metabolomic study, we measured plasma levels of four NAEs: palmitoylethanolamide (PEA), oleoylethanolamide (OEA), stearoyl ethanolamide (SEA), and linoleoyl ethanolamide (LEA) in natives from Puno (3830 m), a ...

The study was conducted in 16 cyclic mares of the Peruvian Paso breed from the province of Ascope, La Libertad, Peru, between January and March 2017, to evaluate the effect of deslorelin acetate administration on ovulation time and pregnancy rate. There was a control group (n=8) without treatment and an experimental group (n=8) treated with 1.75 mg of deslorelin acetate when observing a dominant follicle of 38-40 mm and a grade 2 to 3 of edema endometrial determined by ultrasound. The mares were inseminated at 16-24 h afterwards. The ultrasound monitoring was continued until ovulation and pregnancy diagnosis was done 13-15 days after ovulation. The ovulation time was 43.13 ± 4.48 and 69.00 ± 8.41 h for the experimental and control group, respectively. Ovulation within 48 h occurred in 87.5% (7/8) of the mares in the treated group, while only in 37.5% (3/8) of the control group did. The...

The study was conducted in 16 cyclic mares of the Peruvian Paso breed from the province of Ascope, La Libertad, Peru, between January and March 2017, to evaluate the effect of deslorelin acetate administration on ovulation time and pregnancy rate. There was a control group (n=8) without treatment and an experimental group (n=8) treated with 1.75 mg of deslorelin acetate when observing a dominant follicle of 38-40 mm and a grade 2 to 3 of edema endometrial determined by ultrasound. The mares were inseminated at 16-24 h afterwards. The ultrasound monitoring was continued until ovulation and pregnancy diagnosis was done 13-15 days after ovulation. The ovulation time was 43.13 ± 4.48 and 69.00 ± 8.41 h for the experimental and control group, respectively. Ovulation within 48 h occurred in 87.5% (7/8) of the mares in the treated group, while only in 37.5% (3/8) of the control group did. The...