Objective. The objective of the study was to explore predictive variables of mortality in patients with COPD in Colombia. Materials and methods. Case-control study, in adult patients, diagnosed with COPD, treated at the clínica Comfamiliar, Risaralda, from January 1, 2015 to December 31, 2018. Deceased patients were called cases, and the control group was survivors. A data collection instrument validated by expert judgement was used. A multivariate logistic regression analysis was performed, followed by post-modeling analysis for validation. The analyzes were carried out in Stata 14, official version. It was considered significant with p value <0.05. The project was approved by the bioethics committee of the clínica Comfamiliar. Results. 230 patients with a diagnosis of COPD were included. The mortality rate was 10%, for which there were 23 cases. In the multivariate analysis, the p...