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artículo

Geographic EBV variants confound disease-specific variant interpretation and predict variable immune therapy responses

Publicado por
Briercheck, EL, Ravishankar, S, Ahmed, EH, Alvarado, CCC, Menéndez, JCB, Silva, O, Solórzano-Ortiz, E, Tala, MMS, Stevenson, P, Xu, Y, Wohns, AW, Enriquez-Vera, D, Barrionuevo, C, Yu, S-C, Freud, AG, Oakes, C, Weigel, C, Weinstock, DM, Klimaszewski, HL, Ngankeu, A, Mutalima, N, Samayoa-Reyes, G, Newton, R, Rochford, R, Valvert, F, Natkunam, Y, Shustov, A, Baiocchi, RA, Warren, EH

Publicado 2024

Enlace

Epstein-Barr virus (EBV) is a potent carcinogen linked to hematologic and solid malignancies and causes significant global morbidity and mortality. Therapy using allogeneic EBV-specific lymphocytes shows promise in certain populations, but the impact of EBV genome variation on these strategies remains unexplored. To address this, we sequenced 217 EBV genomes, including hematologic malignancies from Guatemala, Peru, Malawi, and Taiwan, and analyzed them alongside 1307 publicly available EBV genomes from cancer, nonmalignant diseases, and healthy individuals across Africa, Asia, Europe, North America, and South America. These included, to our knowledge, the first natural killer (NK)/T-cell lymphoma (NKTCL) EBV genomes reported outside of East Asia. Our findings indicate that previously proposed EBV genome variants specific to certain cancer types are more closely tied to geographic origin ...