The aim of the present study was to examine the relationship between students’ cognitive and self-regulatory strategies, academic engagement, and academic achievement in higher education, analyzing the mediating role of reading comprehension. Different tasks to assess the constructs were administered to 209 students (Mage = 21.71; SD = 4.36). The students' GPA was used as a measure of academic achievement. Significant associations were found between cognitive and self-regulation strategies, academic engagement, reading comprehension, and students' GPA. In addition, a positive association was found between cognitive and self-regulation strategies and academic engagement. Finally, the structural equation model showed that cognitive and self-regulation strategies and academic engagement have direct effects on students' GPA. Additionally, an indirect effect of cognitive and self-regulation...