Objetive: a) To determine residual estrogen plasma levels seven days after conclusion of estrogen administration in postmenopausal women. b) To confirm if there is any difference in plasma levels between oral (0, 625mg conjugated estrogen) and transdermal (50 mg 17 beta estradiol) administration. c) To assess the clinical impact of residual plasma levels with the Blatt Kupperman Postmenopausal Index (BKMI). MATERIAL AND METHODS: Measurements of estrogen plasma levels were done previous to treatment, and in the seventh day following two or four months treatment with oral and transdermal administration. Symptoms were assessed in each three instances. RESULTS: Estrogen plasma levels remain above basal levels aftertwo and fourmonths treatment. The BKMI decreases 70% independently of estrogen plasma levels and route of administration. Conclusions: Estrogen plasma levels remain above basal lev...

Objetive: a) To determine residual estrogen plasma levels seven days after conclusion of estrogen administration in postmenopausal women. b) To confirm if there is any difference in plasma levels between oral (0, 625mg conjugated estrogen) and transdermal (50 mg 17 beta estradiol) administration. c) To assess the clinical impact of residual plasma levels with the Blatt Kupperman Postmenopausal Index (BKMI). MATERIAL AND METHODS: Measurements of estrogen plasma levels were done previous to treatment, and in the seventh day following two or four months treatment with oral and transdermal administration. Symptoms were assessed in each three instances. RESULTS: Estrogen plasma levels remain above basal levels aftertwo and fourmonths treatment. The BKMI decreases 70% independently of estrogen plasma levels and route of administration. Conclusions: Estrogen plasma levels remain above basal lev...