The research entitled "Workload and stress level in nurses by COVID-19 in the Hospital Virgen de la Puerta, Trujillo" had the objective of describing the relationship between workload and stress level in nurses by COVID-19 in the Hospital Virgen de la Puerta, Trujillo, following the theories of Florence Nightingale in relation to the environment and Selye's stress theory linked to health, which were the basis for this study. The research methodology was quantitative, descriptive-correlation, non-experimental-cross sectional approach. The research population consisted of 100 nurses and the sample consisted of 66 of them. The technique was the survey through social networks and the instrument was the questionnaire, which allowed the collection of data that were later analyzed through descriptive statistics and inferential statistics, the latter establishing Kendall's Tau b test as a factor...