Objective: To evaluate the effect of aqueous, acidic and alcoholic extract of dried leaves Erythroxylum coca var coca (coca) on Trichophyton rubrum (TR), Trichophyton mentagrophytes (TM), Microsporum canis (MC) and Candida albicans (CA) in vitro. Materials and methods: Experimental study, which evaluated the presence or absence of growth, the growth rate of fungi from the sowing point compared with their growth in Sabouraud Agar (AS). It was analyzed with Siegel-Tukey, Kruskal-Wallis, with p<0.05. Results: CA group found statistical difference (p<0.05) between groups ethanol 99.9% vs Aqueous, ethanol 99.9% vs HCl 0.01M, ethanol 99.9% vs control, control vs aqueous, HCl 0.01M vs control, TR group found difference (p<0.05) between groups ethanol 99.9% vs HCl 0.01M, ethanol 99.9% vs aqueous, ethanol 99. 9% vs control, HCl 0.01M vs control; TM group found difference (p<0.05) betw...