Vanilla is the orchid of greatest economic interest to the world since the spice of the same name is obtained from it. Vanillin is obtained from its ripened pod, this compound is highly recognized and demanded by the gastronomic, pharmaceutical, and cosmetic industries for the sweet aroma and flavor it emanates. The objective of this work was to carry out a literature review to put into perspective the reader about the sustainability strategies in the vanilla industry in Mexico, as well as the innovations of propagation and in vitro conservation of Vanilla planifolia germplasm. Despite being originally from Mexico, this country ranks third in world production, preceding Madagascar, and Indonesia. This compilation of studies presents biotechnological techniques to increase vanilla production, as well as alternatives that can reduce the negative effects caused by the low genetic accumulati...