Objective: To determine the clinical and epidemiological characteristics of patients with COVID-19 at a high-altitude hospital. Materials and methods: An observational, cross-sectional and analytical study carried out at the Hospital Daniel Alcides Carrión in Huancayo, Peru, located at 3,250 m a.s.l. The population consisted of 2,248 people. COVID-19 was diagnosed through serology testing and/or reverse transcription polymerase chain reaction (RT-PCR) testing. Data were recorded in a questionnaire. For the statistical analysis, the X2 test, Student’s t-test, and bivariate and multivariate logistic regression analyses were used. A p value < 0.05 was considered statistically significant. Results: The study population with a diagnosis of COVID-19 accounted for 760 patients (100 %), most of whom were males (474 individuals; 62.36 %). The average age was 49 years (range: 15 to 95). Most...