Droughts in the Amazon region are expected to increase in frequency and intensity, which would negatively affect the tropical forest, leading to a positive climate–forest feedback loop that could potentially result in the collapse of this ecosystem. In this study, extreme drought conditions were identified in the Peruvian Amazon region for the period 2000–2024 using the maximum cumulative water deficit (MCWD) index, which is related to the tropical forest water stress. The ERA5, CHIRPS, and MSWEP datasets were used to estimate precipitation, while ERA5 data were used for evapotranspiration. This study focuses on the specificities of droughts and the differences across study areas. Six study areas were specified, three of them located in the Loreto department (northern Peruvian Amazon), another centered in Moyobamba city (western Peruvian Amazon), another in Ucayali, in the central Pe...