Objective: To determine the risk factors associated with mortality in patients with COVID-19 at the Regional Hospital of Loreto, Peru 2021. Methodology and materials: Retrospective analytical observational case-control study of adult patients hospitalized for COVID-19 from January to May 2021. Sociodemographic data, comorbidities and laboratory tests were collected on admission. Univariate and bivariate analyzes were performed, using association measures (OR and Chi square), with their respective 95% confidence intervals (95% CI). Results: There was an initial population of 731 medical records of patients hospitalized for COVID-19. We worked with 300 medical records that met all the inclusion criteria, these were divided into two groups: deceased (n=114) and discharged (n=186). The average age of the total (n=300) was 55.9 (IQR: 18-91), with a predominance of males (60.7%). 77.7% of the ...