Drug interactions, pharmacogenetics, and polypharmacy are three highly related areas of study that are involved in individualizing therapy across species. Variations in the response to drugs such as opioids, the presence of receptors and transporters associated with polymorphic genes, as well as pharmacokinetic changes resulting from differences in phase I and phase II metabolism, lead to the existence of a multiplicity of factors that can affect response to drugs. In addition, the joint administration of different active ingredients (polypharmacy) is related to a greater number of drug interactions, which, associated with the pharmacogenetic conditions of the different breeds of dogs, make personalized medicine a very broad field in which veterinary medicine is still taking its first steps. The present work seeks to analyse the current state of knowledge about the variation of the respo...

The aim of this study was to determine the effectiveness of an autovaccine for papilloma caused by canine papillomavirus (CPV) in the facial region in a three-month-old Great Dane dog. A group of papillomas were collected from the patient’s face and analyzed using molecular techniques (amplification of a segment of the gene that codes for the L1 protein by PCR and sequencing). For sequence analysis, the BLAST algorithm was used. The histological study was performed by hematoxylin-eosin staining of the tissue and analysis under a 20X light microscope. An autovaccine was developed from the excised papillomas, which was administered intradermally on four occasions at seven-day intervals. The presence of genotype 1 CPV was established in the papilloma analyzed. Histopathology established the formation of exophytic epidermal papillae supported by a fibrovascular chorion with hyperkeratosis ...

The incidence of infectious diseases in shrimp has increased the use of antibiotics as part of the response of producers, seeking to reduce losses caused by bacterial outbreaks. These treatments often lack knowledge concerning the pharmacological properties of the products. Data for these properties for oxytetracycline in shrimp are presented, being one of the most used antibiotics, in addition to data for other antibiotics.

The incidence of infectious diseases in shrimp has increased the use of antibiotics as part of the response of producers, seeking to reduce losses caused by bacterial outbreaks. These treatments often lack knowledge concerning the pharmacological properties of the products. Data for these properties for oxytetracycline in shrimp are presented, being one of the most used antibiotics, in addition to data for other antibiotics.