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Background and Objective: Some countries in Latin America (LA) may have the greatest increase in the incidence of renal cell carcinoma (RCC) in both sexes in the coming decades, according to some projections. Increasing efforts to study prognostic factors related to RCC may shorten the regional discrepancies, particularly in the scenario of scarce literature in LA, in comparison to Europe or North America. The evaluation of RCC prognosis allows a greater capacity to anticipate outcomes, in addition to a better understanding of tumor biology and the orientation of the proposed treatment. Herein, we provide a review of the main prognostic factors described in different stages of the disease, considering the progress of publications on kidney cancer in LA. Methods: The PubMed database was used to identify studies on this theme, particularly those from LA. Studies by the Latin American Renal...