Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children

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emezones@gmail.com
Detalles Bibliográficos
Autores: Mezones-Holguín, Edward, Bolaños Díaz, Rafael, Fiestas, Víctor, Sanabria, César, Gutiérrez Aguado, Alfonso, Fiestas, Fabián, Suárez, Víctor J., Rodríguez Morales, Alfonso J., Hernández, Adrian V.
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/337985
Enlace del recurso:http://hdl.handle.net/10757/337985
Nivel de acceso:acceso abierto
Materia:Pneumococcal
Pneumococcal vaccines
Cost-effectiveness
Immunization programs
Peru
Pneumonia
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dc.title.es_PE.fl_str_mv Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
title Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
spellingShingle Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
Mezones-Holguín, Edward
Pneumococcal
Pneumococcal vaccines
Cost-effectiveness
Immunization programs
Peru
Pneumonia
title_short Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
title_full Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
title_fullStr Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
title_full_unstemmed Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
title_sort Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
author Mezones-Holguín, Edward
author_facet Mezones-Holguín, Edward
Bolaños Díaz, Rafael
Fiestas, Víctor
Sanabria, César
Gutiérrez Aguado, Alfonso
Fiestas, Fabián
Suárez, Víctor J.
Rodríguez Morales, Alfonso J.
Hernández, Adrian V.
author_role author
author2 Bolaños Díaz, Rafael
Fiestas, Víctor
Sanabria, César
Gutiérrez Aguado, Alfonso
Fiestas, Fabián
Suárez, Víctor J.
Rodríguez Morales, Alfonso J.
Hernández, Adrian V.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mezones-Holguín, Edward
Bolaños Díaz, Rafael
Fiestas, Víctor
Sanabria, César
Gutiérrez Aguado, Alfonso
Fiestas, Fabián
Suárez, Víctor J.
Rodríguez Morales, Alfonso J.
Hernández, Adrian V.
dc.subject.es_PE.fl_str_mv Pneumococcal
Pneumococcal vaccines
Cost-effectiveness
Immunization programs
Peru
Pneumonia
topic Pneumococcal
Pneumococcal vaccines
Cost-effectiveness
Immunization programs
Peru
Pneumonia
description emezones@gmail.com
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-01-08T21:03:06Z
dc.date.available.es_PE.fl_str_mv 2015-01-08T21:03:06Z
dc.date.issued.fl_str_mv 2015-01-08
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Mezones-Holguín E, Bolaños-Díaz R, Fiestas V, Sanabria C, Gutiérrez-Aguado A, Fiestas F, et al. Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children. The Journal of Infection in Developing Countries [Internet]. 15 de diciembre de 2014 [citado 8 de enero de 2015];8(12). Recuperado a partir de: http://www.jidc.org/index.php/journal/article/view/25500653
dc.identifier.issn.es_PE.fl_str_mv 2036-6590
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/337985
dc.identifier.eissn.es_PE.fl_str_mv 1972-2680
dc.identifier.journal.es_PE.fl_str_mv The Journal of Infection in Developing Countries (J Infect Dev Ctries)
identifier_str_mv Mezones-Holguín E, Bolaños-Díaz R, Fiestas V, Sanabria C, Gutiérrez-Aguado A, Fiestas F, et al. Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children. The Journal of Infection in Developing Countries [Internet]. 15 de diciembre de 2014 [citado 8 de enero de 2015];8(12). Recuperado a partir de: http://www.jidc.org/index.php/journal/article/view/25500653
2036-6590
1972-2680
The Journal of Infection in Developing Countries (J Infect Dev Ctries)
url http://hdl.handle.net/10757/337985
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.jidc.org/index.php/journal/article/view/25500653
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv The Journal of Infection in Developing Countries
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
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reponame_str UPC-Institucional
collection UPC-Institucional
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spelling 1f28a07bd389af46a62cfc6f88179f34-1cf8f447703c7ea7e000afd4f10408f99-1780d6d33cfe9118b392e93d2b478d207-1c9f1636febc8a44d1282d177029730c1-12c43142e920cf4d0e45be43983f31569-199511a0bea50d2dff1ed288f552a8d00-1026121196462cc8a3485b3d081c3e16f-1079dd9a8cd6c82a76a61f5a601dc427c-1df1954be75757918c00849433ed0d14a-1Mezones-Holguín, EdwardBolaños Díaz, RafaelFiestas, VíctorSanabria, CésarGutiérrez Aguado, AlfonsoFiestas, FabiánSuárez, Víctor J.Rodríguez Morales, Alfonso J.Hernández, Adrian V.2015-01-08T21:03:06Z2015-01-08T21:03:06Z2015-01-08Mezones-Holguín E, Bolaños-Díaz R, Fiestas V, Sanabria C, Gutiérrez-Aguado A, Fiestas F, et al. Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children. The Journal of Infection in Developing Countries [Internet]. 15 de diciembre de 2014 [citado 8 de enero de 2015];8(12). Recuperado a partir de: http://www.jidc.org/index.php/journal/article/view/255006532036-6590http://hdl.handle.net/10757/3379851972-2680The Journal of Infection in Developing Countries (J Infect Dev Ctries)emezones@gmail.comIntroduction: Pneumococcal pneumonia (PP) has a high burden of morbimortality in children. Use of pneumococcal conjugate vaccines (PCVs) is an effective preventive measure. After PCV 7-valent (PCV7) withdrawal, PCV 10-valent (PCV10) and PCV 13-valent (PCV13) are the alternatives in Peru. This study aimed to evaluate cost effectiveness of these vaccines in preventing PP in Peruvian children <5 yearsold. Methodology: A cost-effectiveness analysis was developed in three phases: a systematic evidence search for calculating effectiveness; a cost analysis for vaccine strategies and outcome management; and an economic model based on decision tree analysis, including deterministic and probabilistic sensitivity analysis using acceptability curves, tornado diagram, and Monte Carlo simulation. A hypothetic 100 vaccinated children/vaccine cohort was built. An incremental cost-effectiveness ratio (ICER) was calculated. Results: The isolation probability for all serotypes in each vaccine was estimated: 38% for PCV7, 41% PCV10, and 17% PCV13. Avoided hospitalization was found to be the best effectiveness model measure. Estimated costs for PCV7, PCV10, and PCV13 cohorts were USD13,761, 11,895, and 12,499, respectively. Costs per avoided hospitalization were USD718 for PCV7, USD333 for PCV10, andUSD 162 for PCV13. At ICER, PCV7 was dominated by the other PCVs. Eliminating PCV7, PCV13 was more cost effective than PCV10 (confirmed in sensitivity analysis). Conclusions: PCV10 and PCV13 are more cost effective than PCV7 in prevention of pneumonia in children <5 years-old in Peru. PCV13 prevents more hospitalizations and is more cost-effective than PCV10. These results should be considered when making decisions about the Peruvian National Inmunizations Schedule.This study was funded by Instituto Nacional de Salud, Lima, PeruRevisión pór paresapplication/pdfengThe Journal of Infection in Developing Countrieshttp://www.jidc.org/index.php/journal/article/view/25500653info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCPneumococcalPneumococcal vaccinesCost-effectivenessImmunization programsPeruPneumoniaCost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian childreninfo:eu-repo/semantics/article2018-06-15T09:34:25ZIntroduction: Pneumococcal pneumonia (PP) has a high burden of morbimortality in children. Use of pneumococcal conjugate vaccines (PCVs) is an effective preventive measure. After PCV 7-valent (PCV7) withdrawal, PCV 10-valent (PCV10) and PCV 13-valent (PCV13) are the alternatives in Peru. This study aimed to evaluate cost effectiveness of these vaccines in preventing PP in Peruvian children <5 yearsold. Methodology: A cost-effectiveness analysis was developed in three phases: a systematic evidence search for calculating effectiveness; a cost analysis for vaccine strategies and outcome management; and an economic model based on decision tree analysis, including deterministic and probabilistic sensitivity analysis using acceptability curves, tornado diagram, and Monte Carlo simulation. A hypothetic 100 vaccinated children/vaccine cohort was built. An incremental cost-effectiveness ratio (ICER) was calculated. Results: The isolation probability for all serotypes in each vaccine was estimated: 38% for PCV7, 41% PCV10, and 17% PCV13. Avoided hospitalization was found to be the best effectiveness model measure. Estimated costs for PCV7, PCV10, and PCV13 cohorts were USD13,761, 11,895, and 12,499, respectively. Costs per avoided hospitalization were USD718 for PCV7, USD333 for PCV10, andUSD 162 for PCV13. At ICER, PCV7 was dominated by the other PCVs. Eliminating PCV7, PCV13 was more cost effective than PCV10 (confirmed in sensitivity analysis). Conclusions: PCV10 and PCV13 are more cost effective than PCV7 in prevention of pneumonia in children <5 years-old in Peru. PCV13 prevents more hospitalizations and is more cost-effective than PCV10. These results should be considered when making decisions about the Peruvian National Inmunizations Schedule.ORIGINALcostefective.pdfcostefective.pdfapplication/pdf915949https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/1/costefective.pdf5e75f2f12aed0132940946f4a1e94f88MD51trueCC-LICENSElicense_urllicense_urltext/plain; charset=utf-849https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52falselicense_textlicense_texttext/html; charset=utf-822901https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/3/license_text29b9d5e95be03707f9d4a2e110421c11MD53falselicense_rdflicense_rdfapplication/rdf+xml; charset=utf-823148https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/4/license_rdf9da0b6dfac957114c6a7714714b86306MD54falseLICENSElicense.txtlicense.txttext/plain; charset=utf-81659https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/5/license.txt1ed8f33c5404431ad7aabc05080746c5MD55falseTEXTcost efective.pdf.txtcost efective.pdf.txtExtracted Texttext/plain46855https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/6/cost%20efective.pdf.txt188fddd973d03c7a2024ad43534dbba8MD56falsecostefective.pdf.txtcostefective.pdf.txtExtracted Texttext/plain46855https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/8/costefective.pdf.txt188fddd973d03c7a2024ad43534dbba8MD58falseTHUMBNAILcost efective.pdf.jpgcost efective.pdf.jpgGenerated Thumbnailimage/jpeg6343https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/7/cost%20efective.pdf.jpg0bcb9dac6a079f3f2c7161ce18b41fbcMD57falsecostefective.pdf.jpgcostefective.pdf.jpgGenerated Thumbnailimage/jpeg114233https://repositorioacademico.upc.edu.pe/bitstream/10757/337985/9/costefective.pdf.jpg824a41733b4c67b6a34ea042ad9252e6MD59false10757/337985oai:repositorioacademico.upc.edu.pe:10757/3379852020-03-26 20:24:36.168Repositorio académico upcupc@openrepository.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Cost-effectiveness analysis of pneumococcal conjugate vaccines in preventing pneumonia in Peruvian children
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