Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea

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oam1998@outlook.com
Detalles Bibliográficos
Autores: Nisar, Shiraz A., Muppidi, Raghunandan, Duggal, Sumit, Hernández, Adrian V., Kalahasti, Vidyasagar, Jaber, Wael, Minai, Omar A.
Formato: artículo
Fecha de Publicación:2014
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/337271
Enlace del recurso:http://hdl.handle.net/10757/337271
Nivel de acceso:acceso abierto
Materia:Sleep apnea
Coronary artery disease
Mortality
Polysomnography
Impaired functional capacity
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dc.title.es_PE.fl_str_mv Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
title Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
spellingShingle Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
Nisar, Shiraz A.
Sleep apnea
Coronary artery disease
Mortality
Polysomnography
Impaired functional capacity
title_short Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
title_full Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
title_fullStr Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
title_full_unstemmed Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
title_sort Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
author Nisar, Shiraz A.
author_facet Nisar, Shiraz A.
Muppidi, Raghunandan
Duggal, Sumit
Hernández, Adrian V.
Kalahasti, Vidyasagar
Jaber, Wael
Minai, Omar A.
author_role author
author2 Muppidi, Raghunandan
Duggal, Sumit
Hernández, Adrian V.
Kalahasti, Vidyasagar
Jaber, Wael
Minai, Omar A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nisar, Shiraz A.
Muppidi, Raghunandan
Duggal, Sumit
Hernández, Adrian V.
Kalahasti, Vidyasagar
Jaber, Wael
Minai, Omar A.
dc.subject.es_PE.fl_str_mv Sleep apnea
Coronary artery disease
Mortality
Polysomnography
Impaired functional capacity
topic Sleep apnea
Coronary artery disease
Mortality
Polysomnography
Impaired functional capacity
description oam1998@outlook.com
publishDate 2014
dc.date.accessioned.none.fl_str_mv 2014-12-16T21:01:51Z
dc.date.available.none.fl_str_mv 2014-12-16T21:01:51Z
dc.date.issued.fl_str_mv 2014-12-16
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
dc.type.other.es_PE.fl_str_mv Articulo científico
format article
dc.identifier.doi.es_PE.fl_str_mv 10.1513/AnnalsATS.201309-315OC
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/337271
dc.identifier.journal.es_PE.fl_str_mv Annals of the American Thoracic Society
identifier_str_mv 10.1513/AnnalsATS.201309-315OC
Annals of the American Thoracic Society
url http://hdl.handle.net/10757/337271
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201309-315OC#.VJCdb9IrfTo
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv The American Thoracic Society
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/1/AnnTropical.pdf
https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/2/license.txt
https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/3/AnnTropical.pdf.txt
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spelling 0b6dbbc2fb75911ddf82b0632cb5b33c-115b71edd2c7fcd5219de963833464746-171b3e1e4504fe41e99197917eb9f4e5d-1df1954be75757918c00849433ed0d14a-199f4becc566e2a4cb6a8f3fa4565c451-1d6e67b94f720a7fa9ddda87ce973b5c2-1adbd879541b477f51de479cd19294a64-1Nisar, Shiraz A.Muppidi, RaghunandanDuggal, SumitHernández, Adrian V.Kalahasti, VidyasagarJaber, WaelMinai, Omar A.2014-12-16T21:01:51Z2014-12-16T21:01:51Z2014-12-1610.1513/AnnalsATS.201309-315OChttp://hdl.handle.net/10757/337271Annals of the American Thoracic Societyoam1998@outlook.comBackground: Obstructive sleep apnea (OSA) is associated with increased mortality, for which impaired functional capacity (IFC) has been established as a surrogate. We sought to assess whether IFC is associated with increased mortality in patients with OSA and whether IFC is predictive of increased mortality after accounting for coronary artery disease. Methods: Patients with OSA who underwent both polysomnography testing and exercise stress echocardiogram were selected. Records were reviewed retrospectively for demographics, comorbidities, stress echocardiographic parameters, and polysomnography data. Univariable and multivariable logistic regression analysis was used to evaluate the association between IFC and overall mortality. We then evaluated the variables associated with IFC in the overall population and in the subgroup with normal Duke treadmill score (DTS). Results: In our cohort, 404 (26%) patients had IFC. The best predictors of IFC were female sex, history of smoking, ejection fraction less than 55, increased body mass index, presence of comorbidities, abnormal exercise echocardiogram, abnormal heart rate recovery, and abnormal DTS. Compared with those without IFC, patients with IFC were 5.1 times more likely to die (odds ratio [OR], 5.1; 95% confidence interval [CI], 2.5–10.5; P , 0.0001) by univariate analysis and 2.7 times more likely to die (OR, 2.7; 95% CI, 1.2–6.1; P = 0.02) by multivariate analysis, when accounting for heart rate recovery, DTS, and sleep apnea severity. Among those without coronary artery disease, patients with IFC were at significantly increased risk of mortality (OR, 4.3; 95% CI, 1.35–13.79; P = 0.0088) compared with those with preserved functional capacity. Conclusions: In our OSA population, IFC was a strong predictor of increased mortality. Among those with normal DTS, IFC identified a cohort at increased risk of mortality.Revisión por paresapplication/pdfengThe American Thoracic Societyhttp://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201309-315OC#.VJCdb9IrfToinfo:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCSleep apnea72adaedc-d9db-463e-80cb-5e0739811670600Coronary artery disease6697dfed-f739-48f9-80d9-586841f00e84600Mortalitya8f03c55-dc26-4117-a33f-ce911cbf65c8600Polysomnography17c09bc7-e824-42f6-9e7d-880b873a0137600Impaired functional capacity8f0e8e20-5650-40f8-aebf-73a075b13970600Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apneainfo:eu-repo/semantics/articleArticulo científico2018-06-15T12:41:16ZBackground: Obstructive sleep apnea (OSA) is associated with increased mortality, for which impaired functional capacity (IFC) has been established as a surrogate. We sought to assess whether IFC is associated with increased mortality in patients with OSA and whether IFC is predictive of increased mortality after accounting for coronary artery disease. Methods: Patients with OSA who underwent both polysomnography testing and exercise stress echocardiogram were selected. Records were reviewed retrospectively for demographics, comorbidities, stress echocardiographic parameters, and polysomnography data. Univariable and multivariable logistic regression analysis was used to evaluate the association between IFC and overall mortality. We then evaluated the variables associated with IFC in the overall population and in the subgroup with normal Duke treadmill score (DTS). Results: In our cohort, 404 (26%) patients had IFC. The best predictors of IFC were female sex, history of smoking, ejection fraction less than 55, increased body mass index, presence of comorbidities, abnormal exercise echocardiogram, abnormal heart rate recovery, and abnormal DTS. Compared with those without IFC, patients with IFC were 5.1 times more likely to die (odds ratio [OR], 5.1; 95% confidence interval [CI], 2.5–10.5; P , 0.0001) by univariate analysis and 2.7 times more likely to die (OR, 2.7; 95% CI, 1.2–6.1; P = 0.02) by multivariate analysis, when accounting for heart rate recovery, DTS, and sleep apnea severity. Among those without coronary artery disease, patients with IFC were at significantly increased risk of mortality (OR, 4.3; 95% CI, 1.35–13.79; P = 0.0088) compared with those with preserved functional capacity. Conclusions: In our OSA population, IFC was a strong predictor of increased mortality. Among those with normal DTS, IFC identified a cohort at increased risk of mortality.ORIGINALAnnTropical.pdfAnnTropical.pdfapplication/pdf713737https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/1/AnnTropical.pdfdbd4e9457fb6a1c8c1a01a5285bc12f0MD51trueLICENSElicense.txtlicense.txttext/plain; charset=utf-81659https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/2/license.txt1ed8f33c5404431ad7aabc05080746c5MD52falseTEXTAnnTropical.pdf.txtAnnTropical.pdf.txtExtracted Texttext/plain37753https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/3/AnnTropical.pdf.txt0f3094b82fed6baf14ceca75b4332f8fMD53falseTHUMBNAILAnnTropical.pdf.jpgAnnTropical.pdf.jpgGenerated Thumbnailimage/jpeg128631https://repositorioacademico.upc.edu.pe/bitstream/10757/337271/4/AnnTropical.pdf.jpg3367812bad9a8e12a5ca27a1ec8ee128MD54false10757/337271oai:repositorioacademico.upc.edu.pe:10757/3372712022-10-20 13:08:52.48Repositorio académico upcupc@openrepository.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Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea
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