Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.

Descripción del Articulo

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Detalles Bibliográficos
Autores: Abugattas, J, Llacuachaqui, M, Allende, Y Sullcahuaman, Velásquez, A Arias, Velarde, R, Cotrina, J, Garcés, M, León, M, Calderón, G, de la Cruz, M, Mora, P, Royer, R, Herzog, J, Weitzel, J N, Narod, S A
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/610590
Enlace del recurso:http://hdl.handle.net/10757/610590
Nivel de acceso:acceso embargado
Materia:BRCA1
BRCA2
Peru
Breast cancer
Hereditary
id UUPC_c9d75575ec2ae2f9299c8036d135a00f
oai_identifier_str oai:repositorioacademico.upc.edu.pe:10757/610590
network_acronym_str UUPC
network_name_str UPC-Institucional
repository_id_str 2670
dc.title.es_PE.fl_str_mv Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
title Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
spellingShingle Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
Abugattas, J
BRCA1
BRCA2
Peru
Breast cancer
Hereditary
title_short Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
title_full Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
title_fullStr Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
title_full_unstemmed Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
title_sort Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
author Abugattas, J
author_facet Abugattas, J
Llacuachaqui, M
Allende, Y Sullcahuaman
Velásquez, A Arias
Velarde, R
Cotrina, J
Garcés, M
León, M
Calderón, G
de la Cruz, M
Mora, P
Royer, R
Herzog, J
Weitzel, J N
Narod, S A
author_role author
author2 Llacuachaqui, M
Allende, Y Sullcahuaman
Velásquez, A Arias
Velarde, R
Cotrina, J
Garcés, M
León, M
Calderón, G
de la Cruz, M
Mora, P
Royer, R
Herzog, J
Weitzel, J N
Narod, S A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.email.es_PE.fl_str_mv steven.narod@wchospital.ca
dc.contributor.author.fl_str_mv Abugattas, J
Llacuachaqui, M
Allende, Y Sullcahuaman
Velásquez, A Arias
Velarde, R
Cotrina, J
Garcés, M
León, M
Calderón, G
de la Cruz, M
Mora, P
Royer, R
Herzog, J
Weitzel, J N
Narod, S A
dc.subject.es_PE.fl_str_mv BRCA1
BRCA2
Peru
Breast cancer
Hereditary
topic BRCA1
BRCA2
Peru
Breast cancer
Hereditary
description El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2016-05-23T16:20:52Z
dc.date.available.es_PE.fl_str_mv 2016-05-23T16:20:52Z
dc.date.issued.fl_str_mv 2015-10
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.
dc.identifier.issn.es_PE.fl_str_mv 1399-0004
dc.identifier.pmid.es_PE.fl_str_mv 25256238
dc.identifier.doi.es_PE.fl_str_mv 10.1111/cge.12505
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/610590
dc.identifier.journal.es_PE.fl_str_mv Clinical genetics (Clin Genet.)
identifier_str_mv Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.
1399-0004
25256238
10.1111/cge.12505
Clinical genetics (Clin Genet.)
url http://hdl.handle.net/10757/610590
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.ncbi.nlm.nih.gov/pubmed/25256238
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.es_PE.fl_str_mv John Wiley & Sons, Inc.
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/610590/1/license.txt
bitstream.checksum.fl_str_mv 255616c2e22876c8a237cd50f1bc22a3
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Repositorio académico upc
repository.mail.fl_str_mv upc@openrepository.com
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spelling Abugattas, JLlacuachaqui, MAllende, Y SullcahuamanVelásquez, A AriasVelarde, RCotrina, JGarcés, MLeón, MCalderón, Gde la Cruz, MMora, PRoyer, RHerzog, JWeitzel, J NNarod, S Asteven.narod@wchospital.ca2016-05-23T16:20:52Z2016-05-23T16:20:52Z2015-10Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.1399-00042525623810.1111/cge.12505http://hdl.handle.net/10757/610590Clinical genetics (Clin Genet.)El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.The prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.Revisión por paresengJohn Wiley & Sons, Inc.http://www.ncbi.nlm.nih.gov/pubmed/25256238info:eu-repo/semantics/embargoedAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCBRCA1c3c9a1e5-ee03-49d0-9e04-e370e03bbbbb600BRCA23cbfda6b-3b01-4039-b6e1-23891a46368a600Perud6e19394-1ad0-4de6-8bb9-5ec7e2e6d476600Breast cancere3cbd537-e0af-4571-85e6-bc101aa6680e600Hereditary1aed87c9-a6f9-4cda-93a6-d771d3442ccb600Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.info:eu-repo/semantics/articleThe prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.LICENSElicense.txtlicense.txttext/plain; charset=utf-81702https://repositorioacademico.upc.edu.pe/bitstream/10757/610590/1/license.txt255616c2e22876c8a237cd50f1bc22a3MD51false10757/610590oai:repositorioacademico.upc.edu.pe:10757/6105902019-08-30 08:01:08.117Repositorio académico upcupc@openrepository.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Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
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