Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG

Descripción del Articulo

This work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015.
Detalles Bibliográficos
Autores: Palomares-Reyes, Carlos, Silva-Caso, Wilmer, del Valle, Luis J., Aguilar-Luis, Miguel Angel, Weilg, Claudia, Martins-Luna, Johanna, Viñas-Ospino, Adriana, Stimmler, Luciana, Mallqui Espinoza, Naysha, Aquino Ortega, Ronald, Espinoza Espíritu, Walter, Misaico, Erika, del Valle-Mendoza, Juana
Formato: artículo
Fecha de Publicación:2019
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/625181
Enlace del recurso:http://hdl.handle.net/10757/625181
Nivel de acceso:acceso abierto
Materia:Arbovirus
Dengue
DENV
Diagnosis
Peru
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dc.title.en_US.fl_str_mv Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
title Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
spellingShingle Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
Palomares-Reyes, Carlos
Arbovirus
Dengue
DENV
Diagnosis
Peru
title_short Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
title_full Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
title_fullStr Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
title_full_unstemmed Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
title_sort Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
author Palomares-Reyes, Carlos
author_facet Palomares-Reyes, Carlos
Silva-Caso, Wilmer
del Valle, Luis J.
Aguilar-Luis, Miguel Angel
Weilg, Claudia
Martins-Luna, Johanna
Viñas-Ospino, Adriana
Stimmler, Luciana
Mallqui Espinoza, Naysha
Aquino Ortega, Ronald
Espinoza Espíritu, Walter
Misaico, Erika
del Valle-Mendoza, Juana
author_role author
author2 Silva-Caso, Wilmer
del Valle, Luis J.
Aguilar-Luis, Miguel Angel
Weilg, Claudia
Martins-Luna, Johanna
Viñas-Ospino, Adriana
Stimmler, Luciana
Mallqui Espinoza, Naysha
Aquino Ortega, Ronald
Espinoza Espíritu, Walter
Misaico, Erika
del Valle-Mendoza, Juana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.email.es_PE.fl_str_mv juana.delvalle@upc.pe
dc.contributor.author.fl_str_mv Palomares-Reyes, Carlos
Silva-Caso, Wilmer
del Valle, Luis J.
Aguilar-Luis, Miguel Angel
Weilg, Claudia
Martins-Luna, Johanna
Viñas-Ospino, Adriana
Stimmler, Luciana
Mallqui Espinoza, Naysha
Aquino Ortega, Ronald
Espinoza Espíritu, Walter
Misaico, Erika
del Valle-Mendoza, Juana
dc.subject.en_US.fl_str_mv Arbovirus
Dengue
DENV
Diagnosis
Peru
topic Arbovirus
Dengue
DENV
Diagnosis
Peru
description This work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-03-04T23:04:04Z
dc.date.available.none.fl_str_mv 2019-03-04T23:04:04Z
dc.date.issued.fl_str_mv 2019-04
dc.type.en_US.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.issn.none.fl_str_mv 12019712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2019.01.022
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10757/625181
dc.identifier.journal.en_US.fl_str_mv International Journal of Infectious Diseases
dc.identifier.isni.none.fl_str_mv 0000 0001 2196 144X
identifier_str_mv 12019712
10.1016/j.ijid.2019.01.022
International Journal of Infectious Diseases
0000 0001 2196 144X
url http://hdl.handle.net/10757/625181
dc.language.iso.en_US.fl_str_mv eng
language eng
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dc.format.en_US.fl_str_mv application/pdf
dc.publisher.en_US.fl_str_mv Elsevier B.V.
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico - UPC
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dc.source.journaltitle.none.fl_str_mv International Journal of Infectious Diseases
dc.source.volume.none.fl_str_mv 81
dc.source.beginpage.none.fl_str_mv 31
dc.source.endpage.none.fl_str_mv 37
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spelling Palomares-Reyes, CarlosSilva-Caso, Wilmerdel Valle, Luis J.Aguilar-Luis, Miguel AngelWeilg, ClaudiaMartins-Luna, JohannaViñas-Ospino, AdrianaStimmler, LucianaMallqui Espinoza, NayshaAquino Ortega, RonaldEspinoza Espíritu, WalterMisaico, Erikadel Valle-Mendoza, Juanajuana.delvalle@upc.pe2019-03-04T23:04:04Z2019-03-04T23:04:04Z2019-041201971210.1016/j.ijid.2019.01.022http://hdl.handle.net/10757/625181International Journal of Infectious Diseases0000 0001 2196 144XThis work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015.Background: Huánuco is a central eastern region of Peru whose geography includes high forest and low jungle, as well as a mountain range that constitutes the inter-Andean valleys. It is considered a region endemic for dengue due to the many favorable conditions that facilitate transmission of the virus. Methods: A total of 268 serum samples from patients in Huánuco, Peru with an acute febrile illness were assessed for the presence of dengue virus (DENV) via RT-PCR and NS1, IgM, and IgG ELISA during December 2015 and March 2016. Results: DENV was detected in 25% of samples via RT-PCR, 19% of samples by NS1 antigen ELISA, and 10.5% of samples by IgM ELISA. DENV IgG was detected in 15.7% of samples by ELISA. The most frequent symptoms associated with fever across all groups were headache, myalgia, and arthralgia, with no significant difference between the four test methods Conclusions: In this study, DENV was identified in up to 25% of the samples using the standard laboratory method. In addition, a correlation was established between the frequency of positive results and the serological tests that determine NS1, IgM, and IgG. There is an increasing need for point-of-care tests to strengthen epidemiological surveillance in Peru.Revisión por paresRevisión por paresapplication/pdfengElsevier B.V.https://linkinghub.elsevier.com/retrieve/pii/S1201971219300335info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-sa/3.0/us/Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Academico - UPCInternational Journal of Infectious Diseases813137reponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCArbovirusDengueDENVDiagnosisPeruDengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgGinfo:eu-repo/semantics/article2019-03-04T23:04:04ZTHUMBNAIL10.1016j.ijid.2019.01.022.pdf.jpg10.1016j.ijid.2019.01.022.pdf.jpgGenerated Thumbnailimage/jpeg101462https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/5/10.1016j.ijid.2019.01.022.pdf.jpg2a81c6f6eb1abd6df5aad39842e295ebMD55falseelsevier-thumbnail.pngapplication/octet-stream53826https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/6/elsevier-thumbnail.png56164a4d587f2ae39e8dbb84807411b5MD56falseTEXT10.1016j.ijid.2019.01.022.pdf.txt10.1016j.ijid.2019.01.022.pdf.txtExtracted texttext/plain38707https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/4/10.1016j.ijid.2019.01.022.pdf.txt2040ca57d905abc03f09ba2589c36fc3MD54falseLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/3/license.txt8a4605be74aa9ea9d79846c1fba20a33MD53falseCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/2/license_rdf80294ba9ff4c5b4f07812ee200fbc42fMD52falseORIGINAL10.1016j.ijid.2019.01.022.pdf10.1016j.ijid.2019.01.022.pdfapplication/pdf2121059https://repositorioacademico.upc.edu.pe/bitstream/10757/625181/1/10.1016j.ijid.2019.01.022.pdf945fdecf37683915fdaae4232887f889MD51true10757/625181oai:repositorioacademico.upc.edu.pe:10757/6251812019-08-30 07:42:15.217Repositorio académico upcupc@openrepository.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Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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