Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Detalles Bibliográficos
Autores: Hernández, Adrian V., Guarnizo, Mirella, Miranda, Yony, Pasupuleti, Vinay, Deshpande, Abhishek, Paico, Socorro, Lenti, Hosten, Ganoza, Silvia, Montalvo, Laritza, Thota, Priyaleela, Lazaro, Herbert
Formato: artículo
Fecha de Publicación:2014
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/320267
Enlace del recurso:http://hdl.handle.net/10757/320267
Nivel de acceso:acceso abierto
Materia:Breast cancer
Insulin
Insulin resistence
id UUPC_62f6988eafe1fd2897aea15a36f1af27
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network_acronym_str UUPC
network_name_str UPC-Institucional
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dc.title.es_PE.fl_str_mv Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
title Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
spellingShingle Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
Hernández, Adrian V.
Breast cancer
Insulin
Insulin resistence
title_short Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
title_full Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
title_fullStr Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
title_full_unstemmed Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
title_sort Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
author Hernández, Adrian V.
author_facet Hernández, Adrian V.
Guarnizo, Mirella
Miranda, Yony
Pasupuleti, Vinay
Deshpande, Abhishek
Paico, Socorro
Lenti, Hosten
Ganoza, Silvia
Montalvo, Laritza
Thota, Priyaleela
Lazaro, Herbert
author_role author
author2 Guarnizo, Mirella
Miranda, Yony
Pasupuleti, Vinay
Deshpande, Abhishek
Paico, Socorro
Lenti, Hosten
Ganoza, Silvia
Montalvo, Laritza
Thota, Priyaleela
Lazaro, Herbert
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hernández, Adrian V.
Guarnizo, Mirella
Miranda, Yony
Pasupuleti, Vinay
Deshpande, Abhishek
Paico, Socorro
Lenti, Hosten
Ganoza, Silvia
Montalvo, Laritza
Thota, Priyaleela
Lazaro, Herbert
dc.subject.eng.fl_str_mv Breast cancer
Insulin
Insulin resistence
topic Breast cancer
Insulin
Insulin resistence
description This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2014
dc.date.accessioned.none.fl_str_mv 2014-06-10T00:40:22Z
dc.date.available.none.fl_str_mv 2014-06-10T00:40:22Z
dc.date.issued.fl_str_mv 2014-06-09
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
dc.type.other.es_PE.fl_str_mv Articulo científico
format article
dc.identifier.citation.es_PE.fl_str_mv PLoS ONE 9(6): e99317
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0099317
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/320267
dc.identifier.eissn.none.fl_str_mv 1932-6203
dc.identifier.journal.es_PE.fl_str_mv PLoS ONE
identifier_str_mv PLoS ONE 9(6): e99317
10.1371/journal.pone.0099317
1932-6203
PLoS ONE
url http://hdl.handle.net/10757/320267
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099317
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Public Library of Science (PLoS)
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/320267/1/AVHernandez%20PLoSOne2014.pdf
https://repositorioacademico.upc.edu.pe/bitstream/10757/320267/2/license.txt
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spelling df1954be75757918c00849433ed0d14a-19d4b1720d6cc2b25feeb52e46db91a7e-1933664f0338b6e5b71259f2ab6d68c6b-1035ccb14f2f341b78fc375787881abaf-17d82c5b598ef68a93a813fae0b170f93-154897f404ea81974e0480958a2c37ec6-1ecba1892a69b561564ae8958964d856c-17f82239616fe9dcefb7186a526429360-19437bd5469ea2bbb7826427a67e5cb7b-15e2d243ff3d30434d33ba81e01455ba7-1f5ae9742bebef5accd8eb1d7bdf13319-1Hernández, Adrian V.Guarnizo, MirellaMiranda, YonyPasupuleti, VinayDeshpande, AbhishekPaico, SocorroLenti, HostenGanoza, SilviaMontalvo, LaritzaThota, PriyaleelaLazaro, Herbert2014-06-10T00:40:22Z2014-06-10T00:40:22Z2014-06-09PLoS ONE 9(6): e9931710.1371/journal.pone.0099317http://hdl.handle.net/10757/3202671932-6203PLoS ONEThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Objective: This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women. Study Design: We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models. Results: Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD 20.03, 95%CI 20.32 to 0.27; p = 0.9). Similarly, non-fasting/ fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, 20.21 to 0.34; p = 0.6). Using individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64; OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2 vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMAIR) levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p, 0.00001). Conclusions: Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in women. HOMA-IR levels are slightly higher in women with breast cancer.This study was funded by the Instituto Me´dico de la Mujer, Lima, Peru. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Revisión por paresapplication/pdfengPublic Library of Science (PLoS)http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099317info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCBreast cancere3cbd537-e0af-4571-85e6-bc101aa6680e600Insulin8dfbf6e2-0c13-4116-985e-de7bb5ae4e60600Insulin resistenceade78f23-6aea-44cc-a17f-fc94373e1453600Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysisinfo:eu-repo/semantics/articleArticulo científico2018-06-16T09:14:32ZObjective: This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women. Study Design: We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models. Results: Twenty-two studies (n = 33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD 20.03, 95%CI 20.32 to 0.27; p = 0.9). Similarly, non-fasting/ fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, 20.21 to 0.34; p = 0.6). Using individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64; OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2 vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMAIR) levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p, 0.00001). Conclusions: Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in women. 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Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
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