Baja frecuencia de positividad serológica en pacientes con biopsias histológicamente compatibles con enfermedad celiaca en Perú.

• Autores: Arévalo, F., Roe, E., Arias-Stella Castillo, J., Cárdenas, J., Montes, P., Monge, E.
• Formato: artículo
• Fecha de Publicación: 2014
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/314580
• Enlace del recurso: http://hdl.handle.net/10757/314580
• Nivel de acceso: acceso abierto
• Materia: Enfermedad celiaca; Atrofia de vellosidades intestinales; Linfocitos intraepiteliales; Perú; Celiac disease; Intestinal villous atrophy; Intraepithelial lymphocites; Peru

Objective: to study the frequency of positive serology for celiac disease (CD) in patients with duodenal biopsies suggestive of this disease. Material and methods: cross sectional study. We included patients with duodenal biopsies histologically compatible with CD and antigliadin, antiendomysial and IgA antitransglutaminase antibodies. We defined a “case” of CD if there was a positive biopsy and either antiendomisial or antitransglutaminase positive antibodies. Results: thirty one patients were included in our study. Six were antiendomysial positive and 5 antitransglutaminase positive while the antigliadin was positive in 14 cases. Therefore, out of 31 patients only 10 had a serology compatible with CD and only one had positive both antibodies, antiendomysial and antitransglutaminase. Conclusions: a) we have found that most of the duodenal biopsies compatible with CD are not diagnosed with positive serology; and b) we found a low correlation between serological diagnostic tests.