Triglyceride–glucose index and lipid ratios in women with and without polycystic ovary syndrome: a systematic review and meta-analysis

• Autores: Ulloque-Badaracco, Juan R., Alarcon-Braga, Esteban A., Hernandez-Bustamante, Enrique A., Cabrera-Guzmán, Juan C., Dotto-Vasquez, Giuseppe, Maldonado-Basurto, Gian F., Rivera-Cabrera, Germán, Maita-Arauco, Sherelym H., Horruitiner-Mendoza, Andres A., Herrera-Añazco, Percy, Benites-Zapata, Vicente A., Pérez-López, Faustino R.
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/686651
• Enlace del recurso: http://hdl.handle.net/10757/686651
• Nivel de acceso: acceso abierto
• Materia: glucose; high-density lipoprotein-cholesterol; low-density lipoprotein; meta-analysis; polycystic ovary syndrome; total cholesterol/HDL-cholesterol ratio; triglyceride/HDL-cholesterol ratio; triglyceride–glucose index; https://purl.org/pe-repo/ocde/ford#3.00.00

Background: The pathophysiology of polycystic ovary syndrome (PCOS) is complex and heterogeneous. This systematic review and meta-analysis aimed to determine the triglyceride–glucose index and lipid ratios in women with and without PCOS. Methods: Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride–glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs). Results: The search identified 61 observational studies, including case–control (n = 37), cohort (n = 2), and cross-sectional (n = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared with the control group, the PCOS group presented increased circulating triglyceride–glucose index (n = 9 studies, SMD, 0.41; 95% CI, 0.08–0.74) and total cholesterol/HDL-cholesterol (n = 35 studies, SMD, 1.70; 95% CI, 0.69–2.70), triglyceride/HDL-cholesterol (n = 31 studies; SMD, 0.81; 95% CI, 0.43–1.19), and LDL-cholesterol/HDL-cholesterol (n = 25 studies, SMD, 2.40; 95% CI, 0.45–4.35) ratios. Statistical heterogeneity values were very high (I2 > 90%). The PCOS group displayed significantly higher body mass index and homeostatic model assessment of insulin resistance. The PCOS group was younger than the control group and had a higher total cholesterol/HDL-cholesterol ratio, and other lipid variables were comparable in all groups. Conclusion: Patients with PCOS show significantly higher triglyceride–glucose index and total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol ratios than those without the syndrome.