Antiproliferative and structure activity relationships of amaryllidaceae alkaloids

Descripción del Articulo

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and ha...

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Detalles Bibliográficos
Autores: Cedrón, Juan C., Ravelo, Ángel G., León, Leticia G., Padrón, José M., Estévez-Braun, Ana
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad de Ingeniería y tecnología
Repositorio:UTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.utec.edu.pe:20.500.12815/215
Enlace del recurso:https://hdl.handle.net/20.500.12815/215
https://doi.org/10.3390/molecules200813854
Nivel de acceso:acceso abierto
Materia:Amarylidaceae alkaloids
Antiproliferative activity
SAR
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spelling Cedrón, Juan C.Ravelo, Ángel G.León, Leticia G.Padrón, José M.Estévez-Braun, Ana2021-03-17T18:06:34Z2021-03-17T18:06:34Z2015-07-301420-3049https://hdl.handle.net/20.500.12815/215https://doi.org/10.3390/molecules200813854MoleculesThe antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.application/pdfengMDPIinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Repositorio Institucional UTECUniversidad de Ingeniería y Tecnología - UTECreponame:UTEC-Institucionalinstname:Universidad de Ingeniería y tecnologíainstacron:UTECAmarylidaceae alkaloidsAntiproliferative activitySARAntiproliferative and structure activity relationships of amaryllidaceae alkaloidsinfo:eu-repo/semantics/articleORIGINAL10.3390molecules200813854.pdf10.3390molecules200813854.pdfapplication/pdf815775http://repositorio.utec.edu.pe/bitstream/20.500.12815/215/1/10.3390molecules200813854.pdf886d49c52dcda89dbb1c3047d8b3a11dMD51open accessTEXT10.3390molecules200813854.pdf.txt10.3390molecules200813854.pdf.txtExtracted texttext/plain21543http://repositorio.utec.edu.pe/bitstream/20.500.12815/215/6/10.3390molecules200813854.pdf.txtaf6dfe3336b6c3a4d4e408b1d2c85820MD56open accessTHUMBNAIL10.3390molecules200813854.pdf.jpg10.3390molecules200813854.pdf.jpgGenerated Thumbnailimage/jpeg12597http://repositorio.utec.edu.pe/bitstream/20.500.12815/215/7/10.3390molecules200813854.pdf.jpgd1a6b198f9d0401ff1aab71e9232b96cMD57open access20.500.12815/215oai:repositorio.utec.edu.pe:20.500.12815/2152024-04-10 15:57:35.485open accessRepositorio Institucional UTECrepositorio@utec.edu.pe
dc.title.es_PE.fl_str_mv Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
title Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
spellingShingle Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
Cedrón, Juan C.
Amarylidaceae alkaloids
Antiproliferative activity
SAR
title_short Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
title_full Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
title_fullStr Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
title_full_unstemmed Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
title_sort Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
author Cedrón, Juan C.
author_facet Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
author_role author
author2 Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
dc.subject.es_PE.fl_str_mv Amarylidaceae alkaloids
Antiproliferative activity
SAR
topic Amarylidaceae alkaloids
Antiproliferative activity
SAR
description The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.
publishDate 2015
dc.date.accessioned.none.fl_str_mv 2021-03-17T18:06:34Z
dc.date.available.none.fl_str_mv 2021-03-17T18:06:34Z
dc.date.issued.fl_str_mv 2015-07-30
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format article
dc.identifier.issn.es_PE.fl_str_mv 1420-3049
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12815/215
dc.identifier.doi.es_PE.fl_str_mv https://doi.org/10.3390/molecules200813854
dc.identifier.journal.es_PE.fl_str_mv Molecules
identifier_str_mv 1420-3049
Molecules
url https://hdl.handle.net/20.500.12815/215
https://doi.org/10.3390/molecules200813854
dc.language.iso.es_PE.fl_str_mv eng
language eng
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Universidad de Ingeniería y Tecnología - UTEC
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Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
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